The notion of "tone" for the human body


The notion of myogenic tone of our arteries and a discovery of its regulation - In relation to arterial hypertension


Our arteries have a basal myogenic tone, a basal constriction (vasoconstriction) mediated by smooth muscle cells of the artery wall.

This is regulated by calcium influx; calcium binds to contractile units/springs (sarcomeres) and makes them contract by a sliding mechanism


Vasoconstriction - On the myogenic response of small arteries (arterioles) 

As increased blood flow and therefore increased blood pressure distends (passively) the arterioles, they respond by constriction to prevent damage of irrigated organs
The Bayliss myogenic response (1902).


A discovery on its regulation




Les artères sous pression livrent leurs secrets  v/ @insb_cnrs

Cell Reports 14, 1–9. March 8, 2016.


by staff. "Blausen gallery 2014"




Notes on the discovery


Increased blood flow >
Increased pressure by blood > [Equals to : Increased risk to damage irrigated organs]
Increased distention of cells of the artery >
Distended surface of smooth muscle cells of the artery >
Filamin A transmits pressure signal to calcium channels >
Channels open >
Calcium enters the cell >
Calcium binds to contractile units/springs (sarcomeres) and makes them slide on each other in a contraction movement >
Muscle cell contraction >
Reduction of artery diameter >
Reduction of blood flow >
Protection of irrigated organs





Vessels that carry blood and vessels that carry lymph; New lymph ones have been discovered in the head (2015).

The circulatory system is often seen to comprise both the cardiovascular system, which distributes blood, and the lymphatic system, which circulates lymph.[1]